 | Milla Jovovich | .... | Alice |
 | Sienna Guillory | .... | Jill Valentine |
 | Oded Fehr | .... | Carlos Olivera |
 | Thomas Kretschmann | .... | Major Cain |
 | Sophie Vavasseur | .... | Angie Ashford |
 | Raz Adoti | .... | Sgt. Peyton Wells |
 | Jared Harris | .... | Dr. Ashford |
 | Mike Epps | .... | L.J. |
 | Sandrine Holt | .... | Terri Morales |
 | Matthew G. Taylor | .... | Nemesis |
 | Zack Ward | .... | Nicholai Ginovaef |
 | Iain Glen | .... | Dr. Isaacs |
 | Dave Nichols | .... | Captain Henderson |
 | Stefan Hayes | .... | Yuri Loginova |
 | Geoffrey Pounsett | .... | Mackenzie |
 | Shaun Austin-Olsen | .... | Priest |
 | Geny Walters | .... | Mrs.Priest |
 | Megan Fahlenbock | .... | Marla Mapes |
 | Robert Morelli | .... | Director |
 | Aaron Abrams | .... | Assistant |
 | Chris Benson | .... | Lance Halloran |
 | Martin Martinuzzi | .... | Overworked Detective |
 | Brad Borbridge | .... | Overworked Sergeant |
 | Frank Chiesurin | .... | Sniper |
 | Ron Benjamin | .... | Bum |
 | Kevin Hare | .... | Home Owner/ Scientist |
 | Heather Dick | .... | Older Woman |
 | Alex Courey | .... | Suit #1 |
 | John Detoro | .... | Suit #2 |
 | Billy Khoury | .... | Suit #3 |
 | Sava Drayton | .... | Suit #4 |
 | Nicole Ann St Hill | .... | Undead Gaudy Hooker |
 | Ricardo Betancourt | .... | Burly Cop #1 |
 | Ted Ludzik | .... | Burly Cop #2 |
 | Michelle Latimer | .... | Tech #1 |
 | Catherine Burdon | .... | Tech #2 |
 | Rebecca Sims | .... | Undead Little Girl |
 | Christopher Weedon | .... | Undead Little Boy #1 |
 | Billy Parrott | .... | Security Guard |
 | Derek Asland | .... | Featured Graveyard Undead 1 |
 | Richard Harte | .... | Featured Graveyard Undead 2 |
 | Simon Girard | .... | Chopper Pilot #1 |
 | Dean Copkov | .... | Chopper Pilot #2 |
 | Jeff White | .... | Chopper Pilot #4 |
 | Tim Burd | .... | Refugee #1 |
 | Natalie Charles | .... | Refugee #2 |
 | Pierre Henry | .... | Screaming Soldier |
 | Jim Codrington | .... | Lieutenant |
 | Deborah Valente | .... | Tech |
 | Kelly Fiddick | .... | Reflection Undead |
 | Malcolm Xerxes | .... | Featured City Hall Undead #1 |
 | Michy Gustavia | .... | Featured City Hall Undead #2 |
 | Shane Mackinnon | .... | Featured City Hall Undead #3 |
 | Ed Fielding | .... | Featured City Hall Undead #4 |
 | Stephen Hart | .... | Featured City Hall Undead #5 |
 | Sandi Stahlbrand | .... | Reporter #1 |
 | Chris Marren | .... | Guard |
 | Tom Gerhardt | .... | Zombie Dad |
 | Amber Marshall | .... | Daughter |
 | Venice Grant | .... | Undead Stripper #1 |
 | Ana Danilina | .... | Undead Stripper #2 |
 | Ingrid Johansson | .... | Featured IV Woman Undead |
 | Jeffrey Weedon | .... | Undead Little Boy #2 |
 | Melanie Tonello | .... | Featured Undead Kid #1 |
 | Annabel Chu | .... | Featured Undead Kid #2 |
 | Joey Jefferson | .... | Featured Undead Kid #3 |
 | Heather Braaten | .... | Featured Rooftop Undead #1 |
 | Richard Harte | .... | Featured Rooftop Undead #2 |
 | Joey Beck | .... | Featured Rooftop Undead #3 |
 | Eric Morgan | .... | Featured Undead City Walker #1 |
 | Gene Pyrz | .... | Featured Undead City Walker #2 |
 | Torquil Colbo | .... | Featured Undead City Walker #3 |
 | Joan Moore | .... | Featured Undead City Walker #4 |
 | Peter C. Wylde | .... | Featured Undead City Walker #5 |
 | Garry Geddes | .... | Featured Undead City Walker #6 |
 | Dionne Renee | .... | Featured Undead City Walker #7 |
 | Janessa Crimi | .... | Featured Undead Kid #4 |
 | Dan Ellery | .... | Featured "Surplus" Undead #1 |
 | Sharon Moore | .... | Featured "Surplus" Undead #2 |
 | Derek Aasland | .... | Featured "Surplus" Undead #3 |
 | Jo Chim | .... | Network Anchor #1 |
 | Bobby Prochaska | .... | Network Anchor #2 |
 | Jazz Mann | .... | Reporter #2 |
 | Larissa Gomes | .... | Reporter #3 |
 | Gregory White | .... | Lab Technician |
 | Roman Podhora | .... | Leader Umbrella Guard |
 | Brian King | .... | Umbrella Gate Guard |
 | Rob Hall | .... | Featured School Undead |
Flashbacks from RESIDENT EVIL: |
 | Eric Mabius | .... | Matt Addison |